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One curious characteristic of the Spitz tumor pathway is inactivation of CDKN2A (often the only genetic alteration), with loss of p16 expression, which would be of concern in melanocytic tumors in any other pathway.47 Therefore, malignant transformation requires other mutations in addition to inactivation of CDKN2A, for example, TERT promoter mutations

Therefore, to properly improve and establish the clinical beneficial effects of high doses of L-C in CAD patients, further long-term and large-scale intervention studies are needed

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All analyses were performed in accordance with the intention-to-treat (ITT) principle, defined as all randomized participants taking at least one dose of the trial drug