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[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Pagnotta S, Tramutola A, Barone E, Di Domenico F, Pittal V, Salerno L, Folgiero V, Caforio M, Locatelli F, Petrini S, et al

Transgenic mice overexpressing ornithine and S-adenosylmethionine decarboxylases maintain a physiological polyamine homoeostasis in their tissues

24 , 10121030 (2011) Jian, W., Yao, M., Zhang, D., Zhu, M.: Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching

IAA, a pathway for indole production by tryptophan metabolism in Escherichia and others, was shown to be effective in the production of indole via the AHR signaling pathway [182] in VEGF-treated human umbilical vein endothelial cells (HUVEC) exerts anti-angiogenic effects and is able to inhibit VEGF receptor-2 and eNOS phosphorylation in HUVEC cultures with reduced NO production and decreased vasodilatory capacity [183]

Later, similar observations were made in gastrointestinal tumors, neuroblastomas, renal tumors, thyroid tumors, and testicular tumors 125,126