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McKnight, K

Research has also revealed that effector CD8+ T cells characterized by high expression of granzyme K (GzmK) and low expression of granzyme B (GzmB) and perforin have relatively weak cytotoxic effects, driving the development of LN inflammation through the secretion of cytokines (207, 212, 213)

The effect of E2 on increased expression of fatty acid transport protein FAT/CD36 and fatty acid binding protein, as well as transcription factors and key enzymes that regulate oxidative metabolism (197, 203, 260), likely underlie these observations in males

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