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Evidence Quality Gap The most important dimension of this comparison is the quality and scale of the clinical evidence
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doi: 10.1021/acs.biochem.8b00561 97 PortilloFVazquezJPajaresMA
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In the key Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron 36 mg produced mean body weight reductions of 11.2% at 72 weeks in adults with obesity, with nearly 55% of participants achieving at least 10% weight loss and 36% achieving 15% or more
