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The reactions that consume NAD are mediated by enzymes involved in the non-oxidative roles of NAD [1-4]

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To address these challenges, various delivery methods have been investigated, including viral vectors, non-viral vectors, and rational design strategies such as chemical modifications, cationic liposomes, polymers, nanocarriers, and biocoupled siRNAs, aimed at enhancing stability and intracellular delivery (Liu F

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Certain populations face elevated risk of developing very high serum B12 levels, though true toxicity remains rare even in these groups