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The content of other critical enzymes in the ASA-GSH cycle, L-1,4-galactonolactone dehydrogenase (GalLDH) and -glutamylcysteine synthetase (-ECS), was determined using assay kits for GalLDH (Solarbio, Beijing, China) and -ECS (D&B, Shanghai, China), based on findings by Wheeler et al

In the words of Jeremy Appleton, ND, chairman of the department of nutrition at the National College of Naturopathic Medicine in Portland, Oregon: If you look in a hospital situation at people who have cancer, AIDS, or other very serious disease, almost invariably they are depleted in glutathione

2 DAVID calculates a modified Fishers exact P -value to demonstrate enrichment

doi: 10.3389/fphar.2021.639009 261 HeinkeL

In plants, glutathione S-conjugates are either sequestered in the vacuole (Coleman et al., 1997