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10.1371/journal.pmed.1000097 [DOI] [PMC free article] [PubMed] [Google Scholar] NIHR (2025)

Fibrotic changes in the skin, which also can be manifested in phymatous rosacea, can be stimulated by B cells through the production of fibrogenic cytokines such as IL-6 and TGF- via TLR [13,124]

REDEFINE 1 included 3,417 participants with overweight or obesity but without diabetes (mean age, 47 years

Improve oxidative stress markers*

Histology and adipocyte size and number analysis Paraffin embedding, slide sectioning and hematoxylin and eosin staining were performed by the Washington University Musculoskeletal Histology and Morphometry core