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Serum is a rich source of various amino acids, proteins, carbohydrates, lipids, hormones, vitamins, growth factors, growth inhibitors, minerals like Na + , K + , Zn 2+ , Fe 2+ , and trace elements [64]

In essence, the ring structures of heterocycles are made up of atoms other than carbon, with oxygen, nitrogen, and sulfur serving as the most common substituents

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Furthermore, esculetin (20-500 M) can induce SOD expression in the leukemia NB4 cells by activating the Nrf2 signaling pathway (31)

Castillejo, G