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Secondly, the side effects remain another challenge to improve the antitumor efficacy of drugs targeting glutamine metabolism

In the human colon carcinoma cell line Caco-2, glutamine deprivation markedly reduced the expression of multiple tight junction proteins, including claudin-1, occludin, and ZO-1 [43]

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As mentioned previously, MAPK also plays an important role in exercise-induced adaptation in skeletal muscle

Because tissue repair in animal models typically requires both new blood vessel formation and coordinated cell movement, some researchers are interested in whether studying the two peptides in combination reveals synergistic effects that aren't apparent when each is studied in isolation