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As already discussed, eNOS uncoupling, due to the various uremic toxins, including asymmetric dimethyl-arginine, is a ROS contributor to oxidative stress and ROS-derived damage in the kidney (Ueda et al

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Rosti, G., Castagnetti, F., Gugliotta, G

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TrxR, thioredoxin reductase Graphical abstract Highlights Thiol-mediated signalling is a central node in the cellular redox network

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