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Second, it is able to induce the combination of ,-unsaturated ketones and GSH through the nucleophilic addition reaction, depleting GSH and reducing the amount of GSH available to combine with chemotherapeutic agents, thus producing an overall GST-inhibitory effect by sensitizing a cell to chemotherapeutic agents

This can be done through oral supplements, B12 injections, or even intravenous therapy for more severe cases

Given that PIP 2 has pleiotropic functions in cells including receptor endocytosis (see below), other potential mechanisms for PIP 2 in LRP6 phosphorylation remain to be explored

[ 13 C 3 , 15 N]-Cysteine-NEM (m/z 251 m/z 158

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