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J Clin Invest 113(1):1418

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Combining the medications raises this risk

Wilmanski et al., 2023): Fewer protective bacteria (like Bifidobacterium, Faecalibacterium, and Akkermansia) More inflammatory Bacteroides Fewer butyrate-producing gut bacteria (like Ruminococcus) Lower overall gut diversity But theres a catch: the subgroup of people who experienced more severe side effects also responded more intensely to statins in general
