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On the other hand, chronic central administration of ghrelin to GH-deficient rats increases body fat by increasing protein expression, mRNA, and lipogenic enzyme expression in WAT including stearoyl-CoA desaturase-1, FAS, ACC, and lipoprotein lipase [149], while it reduces expression of the fat-oxidation promoting CPT1 in the WAT of rats [148] (Figure 9)

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ALIMTA is indicated as monotherapy for the second line treatment of patients with locally advanced or metastatic nonsmall cell lung cancer other than predominantly squamous cell histology

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