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In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation

(Adopted from (122))

Ascorbic acid and glutathione in this cycle can maintain protein stability and cell membrane integrity, and together with APX and GR, constitute the ascorbate-glutathione cycle (Miao et al., 2021)
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You'll see a rubber stopper underneath
