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Based on further analysis of these two mass spectrometry-based studies, we made two observations: one, that a majority of dysregulated proteins had been previously classified as enzymes (55/92

Front Immunol (2019) 10:2519

It activates phase 2 enzymes by signaling through nuclear factor erythroid 2related factor 2 (Nrf-2) and interacting with the Keap1 protein

493 Additionally, to address soft tissue sarcoma resistance to PDT, ZTN@COF@poloxamer nanocapsules were developed, integrating a Zr-based MOF, the photosensitizer Tetrakis (4-carbethoxyphenyl) porphyrin, and the PARP inhibitor Niraparib, where light-activated ROS generation induces apoptosis, enhancing PDT efficacy and blocking DNA repair