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Similarly, Ssu72 expression was significantly increased during human adipocyte differentiation (Fig

Current animal model systems do not fully recapitulate the pathophysiological conditions in human IC/BPS, and targeting specific molecular pathway disruption in animal models might serve as a better option than existing models

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The presence of the apoB-100 protein allows LDL to be recognized by the LDL receptor but the lack of apoE makes the affinity much lower compared to that of IDL

While this research has revealed highly conserved physiological pathways (e.g., the ipRGC-SCN-melatonin axis), significant limitations exist: (1) Species differences: Human reproductive endocrine regulation is more complex and more sensitive to psychosocial factors