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doi: 10.1126/science.1103538 132 SuggittA

Phenolic compounds work as antioxidants and protect neurons from oxidative damage, preserving their structural and functional integrity (152)

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To identify the pathway by which -oxidation and ER homeostasis are linked, we first asked whether etomoxir (ET), which blocks -oxidation by inhibiting the CPT1-dependent transport of fatty acyl-CoAs into the mitochondria for oxidation (Weis et al., 1994, Yao et al., 2018), could diminish ER stress signaling in primary hepatocytes in vitro as it does in the liver in vivo (see Transparent Methods)

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