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A novel rodent model of autism: intraventricular infusions of propionic acid increase locomotor activity and induce neuroinflammation and oxidative stress in discrete regions of adult rat brain

Environ Toxicol Pharmacol 74:103312

108,109 The decrease in mitochondrial membrane potential induces PINK1 aggregation and autophosphorylation on the outer mitochondrial membrane, which recruits Parkin to initiate the PINK1-Parkin mitophagy pathway to remove damaged mitochondria

Succinate not only increases intracellular ROS levels but also upregulates IL-1 and TNF-, further activating NLRP3 inflammasome assembly