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The genetic manipulation used in the study produced a striatum-wide increase in the D1/D2 receptor ratio from early ages, which has clinical validity given the findings of low D2 receptor availability 51,52,53 and no changes to D1Rs in AUD positive individuals across the striatum 54 , suggesting that D1/D2 receptor ratio might also differ among humans with a history of alcohol abuse

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The latter is found naturally within the cells of the thymus organ and encoded by the TMSB4X gene