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The antioxidant defense grid is complemented by thioredoxin (Trx), a key antioxidant that regulates the dithiol [(R-SH) 2 , reduced form]disulfide (RSSR, oxidized form) balance of interacting proteins (Samoylenko et al

We have produced a large-scale computational biology analysis of the SNO-proteome in the cortex of Shank3 mutant mice (a popular model of ASD [171, 282, 283]) and found that among the NO-related molecular alterations, the most prominent change was the activation of the mTOR signaling pathway [171, 176]

Nat Rev Drug Discov 17(3):183196 Cuadrado A (2022) Brain-protective mechanisms of transcription factor NRF2: toward a common strategy for neurodegenerative diseases
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[18] Systemic side effects may include headache, irritability, restlessness, depression, fatigue, or edema resulting from fluid retention