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Description
Permanent activation of Nrf2 by the genetic knockout of its negative regulator KEAP1 is extremely unfavorable for the organism: newborn knockout mice die quickly from starvation, most likely due to increased expression of -keratins and subsequent gastrointestinal keratosis [88]
They have noticed a visible difference in their skin tone, texture, and overall health
doi: 10.1016/j.exger.2021.111543 82
Statistical analysis was conducted using the non-parametric MannWhitney test
Saffron is contraindicated in pregnancy due to its potential to cause uterine contractions and in individuals with known allergies to saffron or related plants
