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In Parkinsons disease, curcumin inhibits DNMTs, leading to demethylation and reactivation of neuroprotective genes like Nurr1, DJ-1, and PARK genes, and acts as an HDAC inhibitor to enhance histone acetylation, promoting transcription of genes involved in neuronal survival and synaptic plasticity
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doi: 10.1089/gtmb.2013.0309
Mitochondrial fatty acid oxidation disorders: pathophysiological studies in mouse models
Various other potential antitumor compounds, including 2-methoxy-6-acetyl-7-methyljuglone [255], chlorpyrifos (an organophosphate pesticide) [260], and FTY720 (a sphingosine-1-phosphate receptor modulator) [259], have been found to exert cytotoxic effects on various GBM cancer cells by targeting NQO1
