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Given that LCL-161 is currently undergoing phase 2 clinical trials for MM, these findings suggest that SMs may offer additional clinical benefits by mitigating bone degradation in myeloma patients (8)

The FDA does not approve compounded medications for safety, quality, or manufacturing

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however, GSH levels in liver, lung, pancreas, erythrocytes, and plasma of these animals are 916% of that wild type littermates, and cysteine levels are 9, 35, and 40% of that of wild type mice in kidney, pancreas, and plasma, respectively, but are unchanged in the liver and erythrocytes (Yang et al., 2002)