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10.1016/j.biopha.2018.04.056

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One of the key players in coffees potential benefits is, not surprisingly, caffeine, which can boost metabolism temporarily

Induce cytochrome P450 3A4 (CYP3A4) liver enzymes Increase the breakdown of hormones Decrease the effective dose (bioavailability) of the hormone medicines Clarithromycin, a long-term treatment for hypersomnias, is a P450 inhibitor and has the opposite effect

174,175 Clinical trials have also indicated -GCP may be beneficial in patients with dementia disorders as well as after cerebrovascular events like transient ischemic attack (TIA) and stroke