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It functions as a cytosolic second messenger by binding to Ins(1,4,5)P 3 receptors, which are located on the endoplasmic reticulum membrane and operate as ER Ca 2+ release channels

10.1126/science.aah4968 255 NahmodN

Escobar et al

Xue-Chun Hu, [email protected] These authors have contributed equally to this work This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers