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[11] reported that NNMT knockdown improves glucose tolerance and insulin sensitivity in diet-induced obese mice

In vitro , they found that NNMT knockdown significantly lowers hepatocyte glucose output (50%) and that NNMT overexpression significantly increases hepatocyte glucose output (1.4-fold) [14]

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Reduces adiposity, sustains muscle function, and optimizes glucose metabolism

It stimulates endogenous growth hormone (GH) secretion, thereby increasing insulin-like growth factor-1 (IGF-1) levels and promoting lipolysis