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What is supported in animal models Increased lipolysis, increased fat oxidation, decreased lipogenesis, no apparent effect on plasma glucose or insulin sensitivity, and signal that intact beta-3 adrenergic receptor activity matters for the fat-loss effect

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Therapy, such as cognitive behavioral therapy or psychoeducation, can help adolescents learn coping strategies, improve social skills, and manage symptoms

At the same time, the brain tissue is rich in unsaturated fatty acids and transition metal ions yet has relatively fewer antioxidants comparing to other organs creating favorable conditions for oxidative damage