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Clinical Lymphoma, Myeloma and Leukemia 17(10):S3-S4, 2017

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Interestingly, as -arrestins function as physical and biochemical scaffolds that anchor and recruit endocytic machinery as well as components of the MAPK pathway to endosomes, it is possible that -arrestins may limit ERK translocation to the nucleus, thus promoting cytoplasmic ERK signaling (Bond et al., 2019)

Regulatory agencies will need to establish clear standards for botanical drug preparations, similar to Active Pharmaceutical Ingredient (API) standards for single compounds, to facilitate wider acceptance