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The elevated levels of proinflammatory cytokines and chemokines such as tumour necrosis factor (TNF)-, interleukin 1 (IL-1), IL-6, IL-8 [2,7] and others indicate the cytokine storm plays a central role in the immunopathology of COVID-19, but the primary source or the exact virological mechanisms behind it have not been identified yet [8]

b) frameshift mutations, which involve disturbances in the DNA sequence due to the addition or subtraction of nucleotides in the newly synthesized DNA strand

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