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For reproductive applications, this strategy is often well suited to mechanistic stratification because it yields stable axes that can be interpreted in terms of coherent programs, including progesterone-response attenuation, decidualisation trajectory deficits, inflammatory activation, or metabolic stress, while supporting subsequent assay compression into targeted panels [450]

This role is strongly supported by the developmental conservation between humans and rodents, as fetal GnRH neurons in both species begin expressing AMH and its receptor AMHR2 during migrationa pattern that persists and becomes more pronounced into adulthood 66

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DOI: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-50418-1 Online ISBN: 978-3-031-50419-8 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0) Keywords Antedrugs Bioactivation Biotransformation Codrugs Conjugation CYP3A4 CYP450 Cytochrome P450 Drug biotransformation Drug disposition Drug elimination Drug metabolism Efflux transporters Enzyme induction Enzyme inhibition Functionalization reactions Glucuronide Liver Metabolite Mutual prodrugs Personalized Medicine Phase I reactions Phase 1 reactions Phase II reactions Phase 2 reactions Precision Medicine Prodrugs Soft drugs Stratified Medicine Synthetic reactions

Ferric ions (Fe 3 ), though less reactive, also produce radicals from peroxides