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doi: 10.1212/NXG.0000000000200048

Muscarinic receptor agonists and antagonists: Effects on ocular function

To additionally validate the connection between GAPDH and the GLO system, we both knocked down as well as pharmaceutically inhibited GAPDH in two different lung cancer cell lines and found that reducing active GAPDH in all cases enhanced both the expression as well as the activity of the GLO system, validating GAPDH as a master regulator of glucose metabolism and dicarbonyl stress, and with it, a critical drug target in lung cancer

Its delivery model and reimbursement pathway are intended to align with established SSRI therapies, with potential advantages in scalability, patient access and long-term adherence

Food chem