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Endogenous and synthetic ABHD5 ligands regulate ABHD5perilipin interactions and lipolysis in fat and muscle

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Instead, AOD 9604 is used to study downstream metabolic processes, particularly adipose tissue signaling and lipid metabolism, without activating the broader endocrine cascade associated with the GH axis

The foundational obesity finding comes from Kraus and colleagues (Nature, 2014), who showed that knocking down NNMT protected mice against diet-induced obesity establishing NNMT as a metabolic target in the first place

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