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In temporal lobe epilepsy (TLE), reelin gene hypermethylation disrupts the dispersion of granule cells and the expression of reelin (224, 225)

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Figure 4 5.10 Summary of ferroptosis-targeted therapeutic strategies Based on the disease-specific discussions above, ferroptosis-targeted therapeutic strategies can be categorized into three main approaches based on their mechanisms of action: Iron Chelators (e.g., Deferoxamine, Deferiprone) sequester labile iron to limit Fenton chemistry-driven hydroxyl radical generation

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