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Journal of Alzheimers disease : JAD 26:4758

Besides biological systems similarly altered in vitamin D deficiency and RLS, the role of vitamin D in the modulation of neurotransmitters reportedly altered in RLS, might indicate a rationale to consider D3 supplementation, at least as an add-on therapy, in resistant RLS with known vitamin D deficiency, once all other traditional RLS therapeutic options have been exploited

Ascorbic acid is also necessary for the transformation of cholesterol to bile acids as it modulates the microsomal 7 -hydroxylation, the rate limiting reaction of cholesterol catabolism in liver