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SchwertassekUBalmerYGutscherMWeingartenLPreussMEngelhardJet al

2007 Nov 23;92(4):575-82

Efforts directed toward finding new receptors that enable higher selectivity and transport capacity have had limited success thus far

Many metabolic pathways were impacted, presumably due to mitochondrial malfunction, oxidative stress, and endothelial damage in individuals with DR, according to metabolic pathway analysis

[56] Role of fructose 2,6-bisphosphate By binding to its allosteric site on PFK-1 , fructose 2,6-bisphosphate increases the affinity of the enzyme for fructose 6-phosphate, its substrate, while counteracting the inhibitory effect citrate and ATP