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Table 1 The difference of clinical trial drugs

By reducing tyrosinase activity, glutathione helps to decrease melanin production, resulting in a lighter and more radiant complexion

Maintains the perennial hydration of the skin The skin requires moisture at all times

Indications: Psoriasis (low doses) Rheumatoid arthritis The most common drug of first choice in guideline-based therapy (Cohen & Mikuls, 2025) Multiple studies have demonstrated that methotrexate has several advantages over other nonbiologic DMARDs including: faster onset of action, greater effiacy, better long term tolerance, less erosive bone damage, improved patient survival, lower cost (Weinblatt et al, 1985

The preparations were observed with a light microscope to assess the degree of skin irritation by means of histopathological scoring