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The significance of this finding for the clinical management of these patients is also becoming clearer

Studies have shown that Erastin can also modulate p53 signaling outside its canonical ferroptosis activity, altering transcriptional programs that regulate cell-cycle progression and stress responses and thereby intensifying cytotoxicity in sensitive tissues (96)

Fer-1 fails to enhance the p53/SLC7A11/GPX4 pathway but improves the Nrf2/ferroptosis inhibitory protein 1 pathway, boosting resistance to LPO (You et al., 2023)

IBD can also have polygenic, monogenic, or pharmacogenetic origins

While Vitamin B12 deficiency correction has been shown to improve skin health and potentially slow vitiligo progression, it is not a guaranteed cure