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Within endosomes, zinc contributes to tethering and fusion by stabilizing zinc-dependent tethering factors, such as the zinc finger protein EEA1, which facilitates SNARE complex assembly and ensures efficient cargo sorting and receptor recycling 99,100

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Moreover, the communication between MAMs and the coordination of Ca 2+ flux from the ER to mitochondria are pivotal for triggering oxidative metabolic stress, a ROS surge, and an ensuing pro-paraptotic Ca 2+ overload in breast cancer cells [153]