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The MWM is an important and the main method for measuring spatial learning and memory [ 26 ]
Paradoxically, although glial-derived S100 promotes neuronal remodeling through Cx43-dependent mechanisms under homeostatic condition, its overexpression during intestinal inflammation triggers widespread glial activation, thereby exacerbating neuroinflammation and neuronal damage (31)
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Finally, the remodeling phase reorganizes this new tissue into functional architecture that can withstand mechanical stress
