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During such an apnoea, a total cessation of electromyographic activity of the breathing muscles would be predicted, and this has been shown, since central apnoea are defined as breathing pauses without ventilatory effort

Over the past decade, the better understanding of the mechanisms that drive resistance to castration has led to the development of next-generation androgen receptor targeting agents such as abiraterone acetate and enzalutamide

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However, clinical trials typically include highly selected patient populations with fewer comorbidities and high adherence rates
