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The clearest demonstration of entrainment could be seen in free-running blind subjects (76, 77) and in sighted subjects kept in a time free environment (78)

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The growth of pico laser treatment shows an openness to lightly clinical interventions that offer effective results with minimal downtime, reinforcing a preference for gentle yet high-impact solutions

Pharmacological interventions are however commonly used for symptomatic relief in people with ME/CFS, for example for pain and sleep, even though evidence from clinical trials in ME/CFS may be lacking. NICE further emphasise a cautious approach to medicines prescribing

10.1016/1074-7613(95)90112-4 Immunity 29 GhoshA.RoyA.LiuX.KordowerJ
