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Mechanistically, -KG decreases Treg differentiation by inhibiting FOXP3 and upregulating inflammatory cytokines such as IFN-, Tbet, and Rorc, suggesting that Th1-type effector T cells are more dependent on glutaminolysis than Treg cells 136

24th International Conference on Pattern Recognition (ICPR) , 34213426 (IEEE, 2018)

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Other studies have used intravenous injection and found isolated mitochondria in various organs, including the brain, suggesting that isolated mitochondria can cross the bloodbrain barrier [15, 43]