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Description
Cyanoenone triterpenoids This class of synthetic pentacyclic triterpenoids derives from the natural compound oleanolic acid [268, 275] , primarily reacts with C151 in KEAP1 by interrupting KEAP1-CUL3 interaction [123], and includes the strongest NRF2 activators currently known [276]
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They have demonstrated potent inhibitory effects on the lipid peroxidation process in various cell models and animal disease models, including OA (Xu W

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Neurofibromin and its inactivation of Ras are prerequisites for osteoblast functioning
