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This results in lower expression of cytokines (TNF-, IL-6, etc.) and adhesion molecules, dampening the vascular inflammation that drives atherosclerosis and hypertensive organ damage (Wang Q

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FASEB J 29(2):611622 Chondrogianni N, Sakellari M, Lefaki M, Papaevgeniou N, Gonos ES (2015b) Proteasome activation delays aging in vitro and in vivo

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This mechanism is driven by IR-induced Nuclear Receptor Coactivator 4 (NCOA4)-mediated ferritinophagy regulation and has been demonstrated in both intestinal and vascular endothelial tissue, contributing to a cascade of free radical and lipid peroxide formation [44,45,46]