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To investigate the effects of dapagliflozin on diabetic kidney disease in mice, the mice were randomly divided into the following groups ( n = 6): normal control group (control), DKD group (DKD), DKD+dapagliflozin treatment group (DKD+Dapa), and DKD+insulin treatment group (DKD+Insulin)

The evidence was based on experimental data only briefly described in the patent and included models of: gastric ulcers, heart damage, liver damage, pancreatic injury, kidney damage, experimental diabetes, fever, edema, rhinitis, bone fracture, burns, skin wounds, hypersensitivity reactions, pupil dilation, colon injury, tumour growth, radiation injury, red blood cell development, fertility and lactation, tooth damage, several types of central and peripheral nerve damage, and survival from infection with Trichinosis (i.e., tapeworms) as well as several viruses

The second deprivation did not modify spine dynamics or density but selectively re-enlarged the spines formed during the first deprivation

Improved Functional Outcomes: Animals treated with AOD-9604 demonstrated shorter periods of lameness, suggesting improved joint function and potentially reduced pain