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2 Ferroptosis and its history Dixon and his colleagues first discovered ferroptosis in 2012 in cancer cells carrying mutations in the renin-angiotensin system (RAS), which is a type of abnormal suicidal cell fate regulated by iron-catalyzed reaction (Dixon et al., 2012) (Figure 1)

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48, 72 We further found that in colonic epithelial cells subjected to colitis causing chemical (DSS treatment), claudin-2 expression is sharply downregulated and that constitutive claudin-2 expression in these cells protected them from DSS-induced cell death

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