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It can be taken orally or applied transdermally for targeted effects

Distribution and tissue retention After absorption, the monoglutamate folates are distributed to tissues and converted to the polyglutamate form by the enzyme folylpolyglutamate synthetase

Cyanocobalamin is also often used as a supplement in people who have trouble absorbing vitamin B12 from their diet

The storage requirements are different for each phase, and the consequences of getting them wrong are different too

[DOI] [PubMed] [Google Scholar] Hirsch E, Graybiel AM, Agid YA (1988) Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinsons disease