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These compounds appear to be effective in extracellular space, where the concentration of antioxidant enzymes is usually much lower than in the intracellular environment
Physiological ROS act as signaling molecules, regulating physiological and metabolic functions and promoting cell proliferation and innate immune response (Mittler, 2017
doi: 10.1016/j.biopha.2019.108612 90 HeLLuNDaiQZhaoYZhaoLWangHet al
Eur Respir Rev 24:141-LP53
doi: 10.1111/acel.13048 164 JohnstonK
