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(2015), in the Bulletin of Experimental Biology and Medicine , tested GHK-Cu in an elevated plus maze model a standard paradigm where increased open-arm exploration indicates reduced anxiety-like behavior in rodents and reported behavioral changes consistent with anxiolytic activity.[11] A related study examined pain-induced aggressive-defensive behavior in rats using mild electrical stimulation to provoke aggression between paired animals

Li X, Zhang C, Mei Y, Zhong W, Fan W, Liu L, et al

In conclusion, to achieve consistent clinical outcomes with antioxidant treatments in brain cancers, rigorous mechanistic studies are required with respect to the types, forms, and stages of brain tumors

Mn-SOD is active as an antioxidant enzyme in the mitochondria, while Cu/Zn-SOD is primarily responsible for the dismutation of superoxide anions in the cytosol (38)

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