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High-dose treatment for moderate-to-severe infection has not yet shown to be an effective lone treatment option and should only be used along with more successful options to date such as corticosteroid, antibody, and antiviral therapy

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these kinases are able to catalyze the phosphorylation of MAPKs, ERK1, and ERK2, thus rank-ordering the MAPK cascade from RAS, RAF, MEK, and finally to ERK [112, 113]

doi: 10.3390/biom10091251

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